NeoComplete Paraneoplastic Evaluation with Recombx®

Test Code

Test Details

Test code: 4620
Type of disorder: Paraneoplastic and Other Antibody Disorders of the CNS
Disease(s) tested for: Paraneoplastic Neurological Syndrome
Tests included:

Technical Information

Clinical Significance: Anti-Hu, anti-CV2, anti-Yo, anti-Ri, anti-CAR, anti-Ma, anti-Ta, anti-Zic4 antibodies, anti-voltage gated calcium channels (VGCC), anti-P/Q type and voltage gated potassium channels (VGKC), anti- Ganglionic AChR, anti-Amphiphysin, anti-NMDA receptor (NR1-subunit), anti-LGI1, anti-CASPR2, and anti-GAD65 are found in patients with the acute or subacute onset of limbic encephalitis, brainstem encephalitis, focal cortical encephalitis, myelitis, cerebellar degeneration, opsoclonus/myoclonus, retinopathy, sensory neuropathy, autonomic dysfunction, Stiff Person Syndrome and/or Lambert-Eaton Myasthenic Syndrome. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases.
Methodology: Automated Nanoliter Scale Immunoassay, ELISA, Radioimmunoassay, Immunofluorescence Assay (IFA)
Reference Range: Negative < or = 120; Borderline 121-200; Positive >200

CPT Coding

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 86255(3), 86341(1), 83519(2), 86596(1), 83520(8)

Specimen Requirements

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Serum
Specimen Stability: Room temperature: 72 hours, Refrigerated: 21 days, Frozen: 28 days
Specimen Requirements: 2 mL (0.5 mL minimum) serum in a Red-top tube or Serum Separator Tube (SST)
Instructions: Serum must be separated from whole blood within 48 hours of collection.

Shipping Considerations

Transport Temperature: Refrigerated
Set-up/Analytic Time: 7-10 days

Additional Resources

Letters of Medical Necessity

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