Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, CBA with Reflex to Titer

Test Code
1523

Test Details


Test code: 1523
Type of disorder: Multiple Sclerosis
Disease(s) tested for: Neuromyelitis Optica, Myelin Disorder, Demyelinating Disease
Profiles that contain this test:
Special Notes: If the MOG Antibody, CBA is positive a semi-quantitative titer will be performed at an additional charge (CPT code 86256).

Technical Information


Clinical Significance: Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin-4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.
Methodology: Cell-based Immunofluorescence Assay
Reference Range: See Laboratory Report

CPT Coding


The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 86255

Specimen Requirements


Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Serum
Specimen Stability: Room temperature: 72 hours, Refrigerated: 45 days, Frozen: 39 days
Specimen Requirements: 2 mL (0.5 mL minimum) serum in a Red-top tube or Serum Separator Tube (SST)
Instructions: Serum must be separated from whole blood within 48 hours of collection. Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Alternate Specimen Type: Cerebrospinal Fluid (CSF)
Alternate Specimen Stability: Room temperature: 72 hours, Refrigerated: 45 days, Frozen: 39 days
Alternate Specimen Requirements: 2 mL (0.5 mL minimum) CSF collected in a plastic screw cap vial

Shipping Considerations


Transport Temperature: Refrigerated
Reject Criteria: Turbid and/or any suggestion of bacterial contamination
Set-up/Analytic Time: 3-7 days

Additional Resources

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