Epilepsy is a group of disorders caused by disturbances with electrical signaling in the brain. According to Epilepsy.com, epilepsy is the most common severe neurological condition, affecting 65 million individuals worldwide and 2 million in the US at any one time. Approximately 150,000 individuals in the US are diagnosed every year, and one-third of patients have poorly-controlled seizures despite trials of several antiepileptic drugs.

Testing for Genetic and Immunologic Causes of Epilepsy

Athena Diagnostics' Epilepsy Advanced Sequencing Evaluations are organized by phenotype in order to make test selection easy and efficient. Panels were created based on International League Against Epilepsy (ILAE) classification and may detect a disease-causing mutation in 48% of patients (Lemke et al.). Genes were chosen based on monogenic disorders for which epilepsy is a key feature according to the Online Mendelian Inheritance in Man (OMIM) database.

Athena Diagnostics also offers testing for autoimmune causes of epilepsy. Autoantibodies to neuronal proteins have been found in the serum and CSF of over 10% of patients with epilepsy, whether newly-diagnosed or established (Brenner et al.). Patients with these pathogenic autoantibodies may respond well to a combination of antiepileptic drugs and immunotherapy.

Our staff of genetic counselors and laboratory directors is available to assist you in the ordering process.


Letters of Medical Necessity

Epilepsy Advanced Sequencing and CNV Evaluation
Sub panels
Generalized, Absence, Focal, Febrile, and Myoclonic Epilepsies
Epileptic Encephalopathy
Developmental Brain Malformations
Intellectual Disability
Neuronal Ceroid Lipofuscinosis
Epilepsy with Migraine
Syndromic Disorders
Infantile Spasms
Complete SCN1A Evaluation

Order the EpilepsyTest Catalog

Medical Affairs Resources

Athena Diagnostics Client Services - (800) 394-4493 Option 2

Athena Diagnostics Genetic Counselors - Genetics@AthenaDiagnostics.com

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Athena Diagnostics knows that epilepsy can be challenging to manage. We are committed to providing quality testing to find the cause of you or your loved one's seizure disorder.

Athena Alliance Program

We offer the Athena Alliance Program to make testing accessible and affordable. Learn more about the program here.

Advocacy Groups 

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