TTR DNA Sequencing Test

Test Code
235

Test Details


Test code: 235
Type of disorder: Peripheral Neuropathy, Hereditary
Disease(s) tested for: Familial Amyloidotic Polyneuropathy, Type 1
Genes Included: TTR
Profiles that contain this test:
Informed Consent Required: This test requires physician attestation that patient consent has been received

Technical Information


Clinical Significance: Detects sequence variants in the Transthyretin (TTR) gene

Typical Presentation: Individuals may present with one or more of distal limb sensory motor neuropathy, autonomic neuropathy, nephropathy, cardiopathy, arrhythmias, gastrointestinal abnormalities and carpal tunnel syndrome
Methodology: Sanger Sequencing
Reference Range: No sequence variants detected

CPT Coding


The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 81404(1)

Specimen Requirements


Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Whole blood
Specimen Stability: Room temperature: 10 days, Refrigerated: 10 days, Frozen: Unacceptable
Specimen Requirements: 8 mL (6 mL minimum) whole blood collected in two (lavender-top) EDTA tubes.
Instructions: Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. 

Shipping Considerations


Transport Temperature: Room temperature
Set-up/Analytic Time: 14-28 days

Additional Resources

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