ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic)

Test Code

Test Details

Test code: 109
Type of disorder: Dementia
Disease(s) tested for: Alzheimer's Disease
Profiles that contain this test:
Informed Consent Required: This test requires physician attestation that patient consent has been received
Special Notes: Athena does not perform ApoE testing for individuals under the age of 18. Pre-test and post-test genetic counseling is strongly recommended.
Patents: 5,508,167 5,716,828 6,027,896

Technical Information

Clinical Significance: Detection of ApoE2, E3, E4 alleles

Typical Presentation: Dementia
Methodology: Restriction Fragment Length Polymorphism (RFLP)
Reference Range: Presence of ApoE2, E3, E4 alleles

CPT Coding

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 81401(1)

Specimen Requirements

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Whole blood
Specimen Stability: Room temperature: 10 days, Refrigerated: 10 days, Frozen: 90 days
Specimen Requirements: 8 mL (6 mL minimum) whole blood collected in two (lavender-top) EDTA tubes.
Instructions: Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing.

Shipping Considerations

Transport Temperature: Room temperature
Set-up/Analytic Time: 7-14 days

Additional Resources

Letters of Medical Necessity

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