ADmark® Alzheimer's Evaluation

Test Code

Test Details

Test code: 178
Type of disorder: Dementia
Disease(s) tested for: Alzheimer's Disease
Tests included:
Informed Consent Required: This test requires physician attestation that patient consent has been received
Special Notes: Athena does not perform ApoE testing for individuals under the age of 18. Pre-test and post-test genetic counseling is strongly recommended.

Technical Information

Clinical Significance: Detection of ApoE2, E3, E4 alleles and levels of Phosphorylated-Tau protein, Total-Tau protein, and Ab42

Typical Presentation: Dementia

Indications for testing: Dementia
Methodology: ELISA, Restriction Fragment Length Polymorphism (RFLP)
Reference Range: Correlation of levels of markers of Phosphorylated-Tau, Total-Tau, and Ab42, Presence of ApoE2, E3, E4 alleles

CPT Coding

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 81401(1), 83520(3)

Specimen Requirements

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Cerebrospinal fluid (CSF) and Whole blood
Specimen Stability: CSF- Room temperature: 72 hours, Refrigerated: 21 days, Frozen: 4 months; Whole blood- Room temperature: 10 days, Refrigerated: 10 days, Frozen: Unacceptable
Specimen Requirements: CSF: 2 mL (0.5 mL minimum); Whole blood: 8 mL (6 mL minimum)
Instructions: CSF: Polypropylene Transfer Tube and Whole blood: Lavender top (EDTA)

CSF: Tubes other than polypropylene are not acceptable.

CSF: Must be shipped on a cold pack or frozen. Whole blood: Ship room temperature or refrigerated

Shipping Considerations

Transport Temperature: Frozen
Set-up/Analytic Time: 14-21 days

Additional Resources

Letters of Medical Necessity

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