| Test code: |
179 |
| Type of disorder: |
Dementia |
| Disease(s) tested for: |
Alzheimer's Disease |
| Genes Included: |
APP, PSEN1, PSEN2 |
| Tests included: |
|
| Informed Consent Required: |
This test requires physician attestation that patient consent has been received |
| Clinical Significance: |
Detects sequence variants in the PS-1, PS-2, and APP genes. Detects duplications in the APP gene.
Typical Presentation: Progressive dementia with onset before age 65 with a positive family history of early-onset Alzheimer's disease |
| Methodology: |
Next Generation Sequencing, Dosage Analysis |
| Reference Range: |
No sequence variation detected |
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
| CPT: |
81405(1), 81406(2), 81479(1) |
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
| Specimen Type: |
Whole blood |
| Specimen Stability: |
Room temperature: 10 days, Refrigerated: 10 days, Frozen: Unacceptable |
| Specimen Requirements: |
8 mL (6 mL minimum) whole blood collected in two (lavender-top) EDTA tubes. |
| Instructions: |
Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. |
| Transport Temperature: |
Room temperature |
| Set-up/Analytic Time: |
21-28 days |