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Test Catalog
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Hypophosphatemic Rickets Evaluation |
#857 |
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| Typical Presentation: |
Hypophosphatemia and osteomalacia, bone deformities and short stature in cases of childhood onset |
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| Indications for Testing: |
Progressive bowing of legs in a child more than 18 months of age with normal vitamin D levels and marked hypophosphatemia
Hypophosphatemia and hyperphosphaturia in the presence of inappropriately normal vitamin D levels at any age
Family history of hypophosphatemic rickets or hypophosphatemic osteomalacia |
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| Disease(s) tested for: |
X-linked Hypophosphatemic Rickets |
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| Test Details |
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| Test Code: |
857 |
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| Profile includes: |
PHEX (Hypophosphatemic Rickets) DNA Sequencing Test, FGF23 (Hypophosphatemic Rickets) DNA Sequencing Test
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| Informed Consent Required: |
Yes |
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| Medicare ABN Required: |
Yes |
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| Technical Information |
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| Utility: |
Detects mutations (including point mutations, deletions, insertions, and rearrangements) in the coding sequences of PHEX and FGF23 genes |
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| Methodology: |
Polymerase Chain Reaction (PCR), DNA sequencing of entire protein coding region of gene |
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| Reference Value: |
No mutation detected |
| CPT Coding |
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The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding
is the sole responsibility of the billing party.
Please direct any questions regarding coding to
the payer being billed.
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| Stacked CPT Code(s): |
83891(1), 83898(26), 83904(26), 83909(1), 83912(1) |
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| Shipping Considerations |
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| Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form. |
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| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10 mL (pediatric minimum: 2 mL) |
| Collection Tube: |
Yellow or lavender top |
| Stability: |
Hemolysis may compromise DNA recovery and integrity after 48 hrs |
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| Storage Conditions: |
For short periods (until shipped) at 4°C |
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| Shipping Conditions: |
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection); ship Monday through Thursday only |
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| Test Turnaround: |
2 - 8 weeks |
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