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Test Catalog
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Early Onset Obesity (MC4R) Evaluation |
#640 |
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| Type of Disorder: |
Obesity |
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| Typical Presentation: |
Severe obesity before age 3 or 4 |
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| Indications for Testing: |
Severe obesity with onset at or before 5 years
Family history of MC4R-related early onset obesity |
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| Test Details |
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| Test Code: |
640 |
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| Profiles that contain this test: |
Early-Onset Obesity Evaluation
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| Informed Consent Required: |
Yes |
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| Medicare ABN Required: |
Yes |
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| Special Notes: |
N/A |
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| Technical Information |
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| Utility: |
Detects mutations in the melanocortin 4 receptor gene (MC4R) |
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| Methodology: |
Polymerase Chain Reaction (PCR), DNA sequencing of entire protein coding region of gene |
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| Reference Value: |
No mutation detected |
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| CPT Code(s): |
83891(1), 83898(3), 83904(3), 83909(1), 83912(1) |
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| Patents: |
5,622,860, 5,703,220 |
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| Shipping Considerations |
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| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10ml |
| Collection Tube: |
Yellow or lavender top |
| Stability: |
Hemolysis may compromise DNA recovery after 48 hrs |
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| Storage Conditions: |
For short periods (until shipped) at 4°C |
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| Shipping Conditions: |
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection); ship Monday through Thursday only |
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| Test Turnaround: |
2 - 8 weeks |
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