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Test Catalog
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Monogenic Diabetes (MODY) Evaluation |
#885 |
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| Type of Disorder: |
Diabetes |
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| Typical Presentation: |
Non-ketotic hyperglycemia in non-obese individuals of any age |
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| Indications for Testing: |
Non-ketotic insulin-sensitive hyperglycemia in individuals of any age; Family history of diabetes |
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| Disease(s) tested for: |
Maturity-Onset Diabetes of Young (MODY) |
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| Test Details |
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| Test Code: |
885 |
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| Profile includes: |
GCK (MODY2) DNA Sequencing and DeletionTest, HNF4A (MODY1) DNA Sequencing and Deletion Test, IPF1 (MODY4) DNA Sequencing Test, TCF1 (MODY3) DNA Sequencing and Deletion Test, TCF2 (MODY5) DNA Sequencing and Deletion Test
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| Informed Consent Required: |
Yes |
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| Special Notes: |
The Complete MODY Evaluation no longer includes negative reflex to CEL DNA Mutation Analysis. The CEL (MODY8) DNA Mutation Analysis may be ordered individually as test code 837. |
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| Technical Information |
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| Utility: |
Detects deletions in the HNF4A, GCK, HNF1A, HNF1B genes and mutations in the HNF4A, GCK, HNF1A, HNF1B and IPF1 |
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| Methodology: |
DNA sequencing, Multiplex Ligation-dependent Probe Amplification |
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| Reference Value: |
No sequence variation or deletion detected |
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| Patents: |
5,541,060, 5,616,483, 5,827,683, 6,187,533, 6,274,310 |
| CPT Coding |
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The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding
is the sole responsibility of the billing party.
Please direct any questions regarding coding to
the payer being billed.
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| Stacked CPT Code(s): |
83891(1), 83898(42), 83900(1), 83901(48), 83904(42), 83909(43), 83912(1), 83914(50) |
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| CPT 2013: |
81405(1), 81406(2), 81479(1) |
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| Shipping Considerations |
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| Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form. |
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| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10ml (pediatric minimum: 2mL) |
| Collection Tube: |
Yellow or lavender top |
| Stability: |
Hemolysis may compromise DNA recovery and integrity after 48 hrs |
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| Storage Conditions: |
For short periods (until shipped) at 4?C |
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| Shipping Conditions: |
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection); ship Monday through Thursday only |
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| Test Turnaround: |
28 days |
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