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Test Catalog
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Complete ALS Evaluation |
#723 |
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| Type of Disorder: |
Motor Neuron Disease |
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| Typical Presentation: |
Symptoms can start in any muscle including distal, proximal, axial, respiratory or bulbar leading to muscle weakness and wasting, increased muscle tone with hyperreflexia, and at times diaphragmatic and/or bulbar weakness. Aytpical forms can include symptoms of dementia, parkinsonism, or both, although frontal and/or temporal congnitive impairment have been reported in up to 50% of ALS patients. |
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| Indications for Testing: |
Prominent UMN or LMN involvement; patients whose families are at risk for ALS; atypical ALS symptoms. |
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| Disease(s) tested for: |
Amyotrophic Lateral Sclerosis |
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| Test Details |
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| Test Code: |
723 |
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| Profile includes: |
ANG DNA Sequencing test, Familial Amyotrophic Lateral Sclerosis (SOD1) DNA Test, FIG4 DNA Sequencing Test, FUS DNA Sequencing Test, TARDBP DNA Sequencing Test
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| Informed Consent Required: |
Yes |
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| Medicare ABN Required: |
Yes |
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| Special Notes: |
All tests performed at Athena Diagnostics laboratories. All tests available as singles except FIG4. |
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| Technical Information |
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| Utility: |
Detects mutations in the most common genes associated with typical ALS, detecting up to 35% of familial forms of ALS. |
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| Methodology: |
DNA Sequencing |
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| Reference Value: |
No mutation detected |
| CPT Coding |
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The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding
is the sole responsibility of the billing party.
Please direct any questions regarding coding to
the payer being billed.
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| Stacked CPT Code(s): |
83891(1), 83898(49), 83904(49), 83909(49), 83912(1)
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| Shipping Considerations |
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| Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form. |
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| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10 ml |
| Collection Tube: |
Lavender top (EDTA) |
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| Storage Conditions: |
Refrigerate |
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| Shipping Conditions: |
Room temperature, avoid freezing; ship within 24 hours of drawing. |
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| Test Turnaround: |
28 days |
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