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Test Catalog
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MEN1 (MEN1) Evaluation |
#818 |
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| Type of Disorder: |
Family Cancer Syndromes |
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| Typical Presentation: |
Hyperparathyroidism, Zollinger Ellison syndrome, pituitary disease |
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| Indications for Testing: |
Tumors in at least two of three target tissues (parathyroid glands, anterior pituitary, duodenum/pancreas); Multiple parathyroid tumors before age 30; Familial idiopathic hyperparathyroidism (FIHPT); Zollinger Ellison syndrome; Family history of MEN1 or FIHPT |
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| Disease(s) tested for: |
Multiple Endocrine Neoplasia Type 1, Zollinger Ellison Syndrome, Familial Idiopathic Hyperparathyroidism |
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| Test Details |
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| Test Code: |
818 |
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| Informed Consent Required: |
Yes |
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| Medicare ABN Required: |
Yes |
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| Technical Information |
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| Utility: |
Detects mutations in the coding sequence of MEN1 |
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| Methodology: |
Polymerase Chain Reaction (PCR), DNA sequencing of entire protein coding region of the MEN1 gene |
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| Reference Value: |
No mutation detected |
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| CPT Code(s): |
83891 (1); 83898 (10); 83904 (10); 83912 (1) |
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| Shipping Considerations |
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| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10 mL (pediatric minimum: 2 mL) |
| Collection Tube: |
Lavender top (EDTA) or yellow top (ACD-A) |
| Stability: |
Hemolysis may compromise DNA recovery and integrity after 48 hrs |
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| Storage Conditions: |
For short periods (until shipped) at 4°C |
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| Shipping Conditions: |
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection); ship Monday through Thursday only |
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| Test Turnaround: |
21-28 days |
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