|
Test Catalog
|
|
Early Onset Obesity (MC4R) Evaluation |
#640 |
|
| Type of Disorder: |
Obesity |
|
| Typical Presentation: |
Severe obesity before age 3 or 4 |
|
| Indications for Testing: |
Severe obesity with onset at or before 5 years
Family history of MC4R-related early onset obesity |
|
| Test Details |
|
| Test Code: |
640 |
|
| Informed Consent Required: |
Yes |
|
| Medicare ABN Required: |
Yes |
|
| Special Notes: |
N/A |
|
| Technical Information |
|
| Utility: |
Detects mutations in the melanocortin 4 receptor gene (MC4R) |
|
| Methodology: |
Polymerase Chain Reaction (PCR), DNA sequencing of entire protein coding region of gene |
|
| Reference Value: |
No mutation detected |
|
| CPT Code(s): |
83891(1), 83898(3), 83904(3), 83909(1), 83912(1) |
|
| Patents: |
5,622,860, 5,703,220 |
|
| Shipping Considerations |
|
| Preferred Specimen Requirements |
| Type: |
Whole blood |
| Minimum Volume: |
10ml |
| Collection Tube: |
Yellow or lavender top |
| Stability: |
Hemolysis may compromise DNA recovery after 48 hrs |
|
| Storage Conditions: |
For short periods (until shipped) at 4°C |
|
| Shipping Conditions: |
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection); ship Monday through Thursday only |
|
| Test Turnaround: |
14-21 days |
|
|
[back to top]
|
