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The OtoDx™ Sensorineural
Hearing Loss Panel, #328
Athena's OtoDx™ Sensorineural Hearing Loss Profile tests for two important genetic causes of non-syndromic, sensorineural hearing loss: the Connexin 26 mutation found on the GJB2 nuclear gene and the A1555G mutation found in the mitochondrial genome. Mutations in the Connexin 26 gene are responsible for causing over 50% of non-syndromic, prelingual, sensorineural hearing loss. The A1555G mitochondrial mutation is associated with an often-preventable cause of hearing loss. Individuals with this mutation are hypersensitive to the ototoxic effects of aminoglycoside antibiotics; therefore, hearing loss associated with this mutation may be prevented in many cases by avoiding exposure to aminoglycoside antibiotics. Additionally, maternal relatives of patients with the A1555G mutation should also avoid exposure to aminoglycoside antibiotics since they are at 100% risk for having inherited or inheriting this mutation and the associated aminoglycoside hypersensitivity. Athena Diagnostics, Inc. reports the results of the Connexin 26 and the A1555G analysis separately because of the important information associated with each mutation. Please review both result reports.
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