Genomic Imprinting
Genomic Imprinting In most cases, autosomal genes are expressed from both chromosomes. For some autosomal genes, however, the gene allele on one of the chromosomes is permanently silenced. This phenomenon is known as “genomic imprinting.” Genes subject to imprinting are methylated differently in sperm and egg, and these methylation patterns later determine whether the gene is expressed or not. The ABCC8 and KCNJ11 genes are located close to a chromosomal region known to contain both maternally and paternally imprinted genes (14).
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